Cytogenetic biclonality in a child with hypocellular primary myelodysplastic syndrome

Eliane Ferreira Rodrigues; Daiane Corrêa de Souza; Adriana Camargo; Rita de Cássia Tavares; Luiz Fernando Bouzas; Maria Helena Ornellas; Teresa de Souza Fernandez

doi:10.1016/j.cancergencyto.2007.05.025

Cytogenetic biclonality in a child with hypocellular primary myelodysplastic syndrome

Cancer Genet Cytogenet. 2007 Oct 1;178(1):70-2. doi: 10.1016/j.cancergencyto.2007.05.025.

Authors

Eliane Ferreira Rodrigues¹, Daiane Corrêa de Souza, Adriana Camargo, Rita de Cássia Tavares, Luiz Fernando Bouzas, Maria Helena Ornellas, Teresa de Souza Fernandez

Affiliation

¹ Cytogenetic Laboratory, Bone Marrow Transplant Center, National Cancer Institute (INCA), Praça Cruz Vermelha, CEP 20230-130, Rio de Janeiro, RJ, Brazil.

PMID: 17889712
DOI: 10.1016/j.cancergencyto.2007.05.025

Abstract

A 13-year-old boy with hypocellular primary myelodysplastic syndrome, classified as refractory cytopenia, underwent umbilical cord blood transplantation. Cytogenetic analysis revealed two rare biclonal chromosomal aberrations, del(17)(p12) and del(11)(q23). Cytogenetic analysis was a valuable tool in diagnosis, in clinical decision-making, and in treatment and follow-up. To our knowledge, this is the first reported case of cytogenetic biclonality involving chromosomes 17 and 11.

Publication types

Case Reports

MeSH terms

Adolescent
Chromosome Aberrations
Chromosome Banding
Chromosome Deletion
Cytogenetic Analysis
Cytogenetics
Fetal Blood / metabolism
Gene Deletion
Humans
In Situ Hybridization, Fluorescence
Male
Myelodysplastic Syndromes / genetics*
Stem Cell Transplantation
Transplantation