Identification of nyasol and structurally related compounds as the active principles from Anemarrhena asphodeloides against respiratory syncytial virus (RSV)

Chem Biodivers. 2007 Sep;4(9):2231-5. doi: 10.1002/cbdv.200790181.

Abstract

Three known phenolic compounds, (-)-(R)-nyasol (= 4,4'-(1Z,3R)-Penta-1,4-diene-1,3-diyldiphenol; 1), its derivative 2, and broussonin A (3)--isolated from the rhizomes of Anemarrhena asphodeloides--were for the first time identified as the active principles capable of efficient respiratory-syncytial-virus (RSV) inhibition. The IC50 values of 1-3 against the RSV-A2 strain, propagated in HEp-2 cells, were determined, their activities being higher than that of the standard antiviral drug ribavirin (IC50 = 1.15 microM). In addition, the known, but inactive, compound 'trans-N-(para-coumaroyl)tyramine' (= (2E)-3-(4-hydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide; 4) was isolated from this plant for the first time.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anemarrhena / chemistry*
  • Antiviral Agents / chemistry
  • Antiviral Agents / isolation & purification
  • Antiviral Agents / pharmacology*
  • Cell Line
  • Humans
  • Inhibitory Concentration 50
  • Lignans
  • Molecular Structure
  • Phenols / chemistry
  • Phenols / isolation & purification
  • Phenols / pharmacology*
  • Respiratory Syncytial Viruses / drug effects*
  • Rhizome / chemistry

Substances

  • 4'-O-methylnyasol
  • Antiviral Agents
  • Lignans
  • Phenols
  • broussonin A
  • nyasol