Abstract
Information on the synthesis and biological activity of natural and synthetic analogues of alpha-tocopherol with a modified side chain is systematized. These compounds are of interest as vitamin E metabolites, hydrophilic antioxidants, and precursors of drugs with combined pharmacological properties useful in therapy of pathological disorders caused by oxidative stress.
MeSH terms
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Animals
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Antioxidants* / chemical synthesis
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Antioxidants* / chemistry
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Antioxidants* / pharmacology
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Humans
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Molecular Structure
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Oxidative Stress / drug effects
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Stereoisomerism
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Structure-Activity Relationship
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alpha-Tocopherol* / analogs & derivatives
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alpha-Tocopherol* / chemical synthesis
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alpha-Tocopherol* / pharmacology
Substances
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Antioxidants
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alpha-Tocopherol