[Racemic and optically active alpha-tocopherol analogues with a modified side chain: synthesis and biological activity]

Bioorg Khim. 2007 Jul-Aug;33(4):387-404. doi: 10.1134/s1068162007040012.
[Article in Russian]

Abstract

Information on the synthesis and biological activity of natural and synthetic analogues of alpha-tocopherol with a modified side chain is systematized. These compounds are of interest as vitamin E metabolites, hydrophilic antioxidants, and precursors of drugs with combined pharmacological properties useful in therapy of pathological disorders caused by oxidative stress.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Animals
  • Antioxidants* / chemical synthesis
  • Antioxidants* / chemistry
  • Antioxidants* / pharmacology
  • Humans
  • Molecular Structure
  • Oxidative Stress / drug effects
  • Stereoisomerism
  • Structure-Activity Relationship
  • alpha-Tocopherol* / analogs & derivatives
  • alpha-Tocopherol* / chemical synthesis
  • alpha-Tocopherol* / pharmacology

Substances

  • Antioxidants
  • alpha-Tocopherol