Abstract
The ethanol extract of Zhumeria majdae showed potent antileishmanial and antiplasmodial activity in vitro. Bioactivity guided fractionation of the extract led to the isolation of 12,16-dideoxy aegyptinone B. This compound exhibited potent in vitro antileishmanial activity with an IC(50) of 0.75 microg/mL and a strong antiplasmodial activity with IC(50) values of 1.3 and 1.4 microg/mL against chloroquine sensitive and resistant strains, respectively. This compound was further found to have mild cytotoxicity towards cancer cell lines.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Animals
-
Antiprotozoal Agents / chemistry
-
Antiprotozoal Agents / pharmacology*
-
Antiprotozoal Agents / toxicity
-
Cell Line
-
Chlorocebus aethiops
-
Diterpenes / chemistry
-
Diterpenes / pharmacology*
-
Ethanol / chemistry
-
Humans
-
Inhibitory Concentration 50
-
Lamiaceae / chemistry*
-
Leishmania donovani / drug effects*
-
Mice
-
Naphthoquinones / chemistry
-
Naphthoquinones / pharmacology*
-
Plant Components, Aerial / chemistry
-
Plant Extracts / chemistry
-
Plant Extracts / pharmacology*
-
Plant Extracts / toxicity
-
Plant Roots / chemistry
-
Plasmodium falciparum / drug effects*
-
Toxicity Tests
-
Vero Cells
Substances
-
12,16-dideoxyaegyptinone B
-
Antiprotozoal Agents
-
Diterpenes
-
Naphthoquinones
-
Plant Extracts
-
Ethanol