Antileishmanial, antiplasmodial and cytotoxic activities of 12,16-dideoxy aegyptinone B from Zhumeria majdae Rech.f. & Wendelbo

Phytother Res. 2008 Mar;22(3):283-5. doi: 10.1002/ptr.2305.

Abstract

The ethanol extract of Zhumeria majdae showed potent antileishmanial and antiplasmodial activity in vitro. Bioactivity guided fractionation of the extract led to the isolation of 12,16-dideoxy aegyptinone B. This compound exhibited potent in vitro antileishmanial activity with an IC(50) of 0.75 microg/mL and a strong antiplasmodial activity with IC(50) values of 1.3 and 1.4 microg/mL against chloroquine sensitive and resistant strains, respectively. This compound was further found to have mild cytotoxicity towards cancer cell lines.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Antiprotozoal Agents / chemistry
  • Antiprotozoal Agents / pharmacology*
  • Antiprotozoal Agents / toxicity
  • Cell Line
  • Chlorocebus aethiops
  • Diterpenes / chemistry
  • Diterpenes / pharmacology*
  • Ethanol / chemistry
  • Humans
  • Inhibitory Concentration 50
  • Lamiaceae / chemistry*
  • Leishmania donovani / drug effects*
  • Mice
  • Naphthoquinones / chemistry
  • Naphthoquinones / pharmacology*
  • Plant Components, Aerial / chemistry
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Extracts / toxicity
  • Plant Roots / chemistry
  • Plasmodium falciparum / drug effects*
  • Toxicity Tests
  • Vero Cells

Substances

  • 12,16-dideoxyaegyptinone B
  • Antiprotozoal Agents
  • Diterpenes
  • Naphthoquinones
  • Plant Extracts
  • Ethanol