Abstract
4-Hydroxybenzyl alcohol (HBA), one of the well-known phenolic compounds in diverse plants, displayed a significant inhibition in the chick chorioallantoic membrane (CAM) angiogenesis assay. HBA was shown to contain an anti-inflammatory activity in carrageenan-induced air pouch model in rats and acetic acid-induced permeability model in mice. Anti-nociceptive activity of HBA was also assessed using the acetic acid-induced writhing test in mice. HBA was able to suppress production of nitric oxide (NO) and expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-activated RAW264.7 macrophages. In the macrophages, the level of reactive oxygen species (ROS) was diminished by HBA. Taken together, HBA possesses anti-angiogenic, anti-inflammatory and anti-nociceptive activity possibly via its down-regulating activity on NO production, which may be partly responsible for the pharmacological efficacy of several folkloric medicines.
MeSH terms
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Analgesics / administration & dosage
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Analgesics / pharmacology*
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Angiogenesis Inhibitors / administration & dosage
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Angiogenesis Inhibitors / pharmacology*
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Animals
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Anti-Inflammatory Agents / administration & dosage
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Anti-Inflammatory Agents / pharmacology*
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Benzyl Alcohols / administration & dosage
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Benzyl Alcohols / pharmacology*
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Capillary Permeability / drug effects
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Chick Embryo
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Chorioallantoic Membrane / blood supply
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Chorioallantoic Membrane / drug effects
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Dose-Response Relationship, Drug
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Down-Regulation / drug effects
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Inflammation / drug therapy
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Macrophages / drug effects
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Macrophages / metabolism
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Male
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Mice
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Mice, Inbred ICR
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Nitric Oxide / metabolism
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Nitric Oxide Synthase Type II / drug effects
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Nitric Oxide Synthase Type II / genetics
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Pain / drug therapy
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Pain Measurement
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Plants, Medicinal / chemistry
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Rats
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Reactive Oxygen Species / metabolism
Substances
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Analgesics
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Angiogenesis Inhibitors
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Anti-Inflammatory Agents
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Benzyl Alcohols
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Reactive Oxygen Species
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4-hydroxybenzyl alcohol
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Nitric Oxide
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Nitric Oxide Synthase Type II