Abstract
An efficient and modular one-pot synthesis of polysubstituted aromatic amines by a mild reductive amination procedure is described and the biological potential of these nitrogen-centered compounds is demonstrated by growth inhibition of murine connective tissue cells and microscopy-based morphological studies.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amines / chemical synthesis*
-
Amines / chemistry
-
Amines / toxicity*
-
Animals
-
Cell Line
-
Cell Proliferation / drug effects
-
Cytotoxins / chemical synthesis*
-
Cytotoxins / chemistry
-
Cytotoxins / toxicity*
-
Drug Evaluation, Preclinical
-
Mice
-
Molecular Structure
-
Potoroidae
-
Stereoisomerism
-
Structure-Activity Relationship