Abstract
The polyether toxin okadaic acid (OA) inhibits several protein serine/threonine phosphatases that play central roles in the regulation of many essential cellular processes. The use of scanning tunneling microscopy (STM) shows that dimerization of such toxins is crucial to understand the mechanism of toxin transport across model membranes.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Cell Membrane / chemistry
-
Cell Membrane / metabolism
-
Enzyme Inhibitors / chemistry
-
Enzyme Inhibitors / pharmacology*
-
Marine Toxins / pharmacology*
-
Microscopy, Scanning Tunneling / methods
-
Models, Biological
-
Molecular Structure
-
Okadaic Acid / chemistry
-
Okadaic Acid / pharmacology*
-
Phosphoprotein Phosphatases / antagonists & inhibitors*
Substances
-
Enzyme Inhibitors
-
Marine Toxins
-
Okadaic Acid
-
Phosphoprotein Phosphatases