Brunneins A-C, beta-carboline alkaloids from Cortinarius brunneus

Axel Teichert; Jürgen Schmidt; Andrea Porzel; Norbert Arnold; Ludger Wessjohann

doi:10.1021/np070259w

Brunneins A-C, beta-carboline alkaloids from Cortinarius brunneus

J Nat Prod. 2007 Sep;70(9):1529-31. doi: 10.1021/np070259w. Epub 2007 Sep 14.

Authors

Axel Teichert¹, Jürgen Schmidt, Andrea Porzel, Norbert Arnold, Ludger Wessjohann

Affiliation

¹ Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120 Halle/Saale, Germany.

PMID: 17854153
DOI: 10.1021/np070259w

Abstract

Four beta-carboline alkaloids, brunneins A-C (1-3) and 3-(7-hydroxy-9H-beta-carboline-1-yl)propanoic acid (4), were isolated from fruiting bodies of the agaricoid fungus Cortinarius brunneus. The structures of 1-3 were determined by analysis of NMR and MS data, and the structure of compound 4 was determined by comparison with published data. Brunnein A (1) exhibited very low cholinesterase inhibitory effects and no cytotoxicity.

MeSH terms

Agaricales / chemistry*
Alkaloids / chemistry
Alkaloids / isolation & purification*
Alkaloids / pharmacology
Animals
Carbolines / chemistry
Carbolines / isolation & purification*
Carbolines / pharmacology
Cholinesterase Inhibitors / chemistry
Cholinesterase Inhibitors / isolation & purification*
Cholinesterase Inhibitors / pharmacology
Drug Screening Assays, Antitumor
Germany
Humans
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular

Substances

Alkaloids
Carbolines
Cholinesterase Inhibitors
brunnein A
brunnein B
brunnein C