Bis(4-hydroxybenzyl)sulfide: a sulfur compound inhibitor of histone deacetylase isolated from root extract of Pleuropterus ciliinervis

Molecules. 2007 Apr 20;12(4):815-20. doi: 10.3390/12040815.

Abstract

A sulfur compound, bis(4-hydroxybenzyl)sulfide (1) was isolated from the root extract of Pleuropterus ciliinervis. Its structure was elucidated using NMR spectroscopic techniques and mass spectrometric analysis. Compound 1 showed potent inhibitory activity in a histone deacetylase (HDAC) enzyme assay. It also exhibited growth inhibitory activity on five human tumor cell lines and more sensitive inhibitory activity on the MDA-MB-231 breast tumor cell line.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry*
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Histone Deacetylase Inhibitors
  • Histone Deacetylases / chemistry*
  • Humans
  • Mass Spectrometry / methods
  • Models, Chemical
  • Plant Extracts / metabolism*
  • Plant Roots / metabolism
  • Sensitivity and Specificity
  • Sulfides / chemistry*
  • Sulfur / chemistry*
  • Sulfur Compounds / chemistry*
  • Tetrazolium Salts / chemistry
  • Thiazoles / chemistry

Substances

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Histone Deacetylase Inhibitors
  • Plant Extracts
  • Sulfides
  • Sulfur Compounds
  • Tetrazolium Salts
  • Thiazoles
  • bis(4-hydroxybenzyl)sulfide
  • Sulfur
  • Histone Deacetylases
  • thiazolyl blue