Abstract
A sulfur compound, bis(4-hydroxybenzyl)sulfide (1) was isolated from the root extract of Pleuropterus ciliinervis. Its structure was elucidated using NMR spectroscopic techniques and mass spectrometric analysis. Compound 1 showed potent inhibitory activity in a histone deacetylase (HDAC) enzyme assay. It also exhibited growth inhibitory activity on five human tumor cell lines and more sensitive inhibitory activity on the MDA-MB-231 breast tumor cell line.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry*
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Histone Deacetylase Inhibitors
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Histone Deacetylases / chemistry*
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Humans
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Mass Spectrometry / methods
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Models, Chemical
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Plant Extracts / metabolism*
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Plant Roots / metabolism
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Sensitivity and Specificity
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Sulfides / chemistry*
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Sulfur / chemistry*
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Sulfur Compounds / chemistry*
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Tetrazolium Salts / chemistry
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Thiazoles / chemistry
Substances
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Antineoplastic Agents
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Enzyme Inhibitors
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Histone Deacetylase Inhibitors
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Plant Extracts
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Sulfides
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Sulfur Compounds
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Tetrazolium Salts
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Thiazoles
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bis(4-hydroxybenzyl)sulfide
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Sulfur
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Histone Deacetylases
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thiazolyl blue