Lower leukocytes at initial diagnosis may predict poor outcome of very late relapse of acute lymphoblastic leukemia

Hideki Nakasone; Michiko Kida; Seiko Iki; Kensuke Usuki

doi:10.1016/j.leukres.2007.07.026

Lower leukocytes at initial diagnosis may predict poor outcome of very late relapse of acute lymphoblastic leukemia

Leuk Res. 2008 Apr;32(4):659-64. doi: 10.1016/j.leukres.2007.07.026. Epub 2007 Sep 11.

Authors

Hideki Nakasone¹, Michiko Kida, Seiko Iki, Kensuke Usuki

Affiliation

¹ Division of Hematology, NTT Kanto Medical Center, 5-9-22 Higashigotanda, Shinagawa-ku, Tokyo 141 8625, Japan. nakasone-tky@umin.ac.jp

PMID: 17850867
DOI: 10.1016/j.leukres.2007.07.026

Abstract

We have reported a rare case of acute lymphoblastic leukemia (ALL) recurring 19 years after the first presentation. Since 1984, 36 relapse cases 10 years or more after the first diagnosis have been reported. All cases were childhood ALL with a low to standard risk. Twenty-six attained CR2, and 18 of them remained in sustained CR2. The sustained CR2 ratio was 80% without transplantation. Sustained CR2 ratio was significantly lower in patients with lower leukocytes (<10 x 10(9)l(-1)) at initial presentation. A very late relapse of ALL remains chemosensitive, and its prognosis is not unfavorable.

Publication types

Case Reports

MeSH terms

Adolescent
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Bone Marrow / pathology
Child
Female
Humans
Leukocyte Count
Male
Neoplasm Recurrence, Local / diagnosis*
Neoplasm Recurrence, Local / prevention & control
Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
Treatment Outcome