Abstract
Two new cytotoxic quinones of the angucycline class, marmycins A and B ( 1, 2), were isolated from the culture broth of a marine sediment-derived actinomycete related to the genus Streptomyces. The gross structures and absolute configurations of both compounds were determined by spectroscopic and crystallographic methods. Marmycin A ( 1) displayed significant cytotoxicity against several cancer cell lines, some at nanomolar concentrations; while compound 2, a chloro analogue of 1, was less potent. For marmycin A ( 1), tumor cell cytotoxicity appeared to coincide with induction of modest apoptosis and arrest in the G1 phase of the cell cycle.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Amphotericin B / pharmacology
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Anthraquinones* / chemistry
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Anthraquinones* / isolation & purification
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Anthraquinones* / pharmacology
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Anti-Bacterial Agents* / chemistry
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Anti-Bacterial Agents* / isolation & purification
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Anti-Bacterial Agents* / pharmacology
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Antibiotics, Antineoplastic* / chemistry
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Antibiotics, Antineoplastic* / isolation & purification
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Antibiotics, Antineoplastic* / pharmacology
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Candida albicans / drug effects
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Crystallography, X-Ray
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Drug Screening Assays, Antitumor
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Enterococcus faecium / drug effects
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Glycosides* / chemistry
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Glycosides* / isolation & purification
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Glycosides* / pharmacology
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Humans
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Marine Biology
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Methicillin Resistance / drug effects
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Molecular Conformation
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Molecular Structure
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Staphylococcus aureus / drug effects
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Streptomyces / chemistry*
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Vancomycin Resistance
Substances
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Anthraquinones
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Anti-Bacterial Agents
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Antibiotics, Antineoplastic
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Glycosides
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marmycin A
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marmycin B
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Amphotericin B