Genetics of psoriasis and psoriatic arthritis

Reumatismo. 2007:59 Suppl 1:25-7. doi: 10.4081/reumatismo.2007.1s.25.

Abstract

Psoriasis and psoriatic arthritis are linked diseases characterised by (distinct ?) immune-mediated pathogenetic mechanisms and by a genetic background interacting with environmental factors. Some candidate susceptibility genes have been studied extensively; they include HLA genes, genes within the HLA region and genes outside the HLA region; among them corneodesmosin and other genes of PSORS1 region, MICA and TNF-a polymorphisms. The main findings in the literature are discussed.

Publication types

  • Review

MeSH terms

  • Alleles
  • Arthritis, Psoriatic / genetics
  • Genetic Markers / genetics
  • Genetic Predisposition to Disease
  • Genotype
  • HLA-C Antigens / genetics
  • Histocompatibility Antigens Class I / genetics
  • Humans
  • Polymorphism, Genetic
  • Proteins / genetics
  • Psoriasis / genetics*
  • Psoriasis / immunology
  • Tumor Necrosis Factor-alpha / genetics

Substances

  • Genetic Markers
  • HLA-C Antigens
  • Histocompatibility Antigens Class I
  • MHC class I-related chain A
  • PSORS1C1 protein, human
  • Proteins
  • Tumor Necrosis Factor-alpha