Anti-platelet aggregation triterpene saponins from the galls of Sapindus mukorossi

Chem Pharm Bull (Tokyo). 2007 Sep;55(9):1412-5. doi: 10.1248/cpb.55.1412.

Abstract

Bioassay-directed fractionation of an ethanolic extract of the galls of Sapindus mukorossi has resulted in the isolation of two new tirucallane-type triterpenoid saponins, sapinmusaponins Q (1) and R (2), along with three known oleanane-type triterpenoid saponins (3-5). Their structures were elucidated on the basis of spectroscopic analysis and chemical hydrolysis. Biological evaluation showed that both sapinmusaponins Q and R demonstrated more potent anti-platelet aggregation activity than aspirin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbohydrate Conformation
  • Carbohydrate Sequence
  • Chromatography, High Pressure Liquid
  • Chromatography, Thin Layer
  • Hydrolysis
  • L-Lactate Dehydrogenase / metabolism
  • Magnetic Resonance Spectroscopy
  • Molecular Sequence Data
  • Plant Extracts / analysis
  • Plant Tumors*
  • Platelet Aggregation Inhibitors / isolation & purification*
  • Platelet Aggregation Inhibitors / pharmacology*
  • Sapindus / chemistry*
  • Saponins / isolation & purification*
  • Saponins / pharmacology*
  • Spectrophotometry, Infrared
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology*

Substances

  • Plant Extracts
  • Platelet Aggregation Inhibitors
  • Saponins
  • Triterpenes
  • sapinmusaponin I
  • sapinmusaponin Q
  • L-Lactate Dehydrogenase