Abstract
Six new caryophyllane-related natural products, including two carboxylated sesquiterpenoids, rumphellolides A (1) and B (2), and four norsesquiterpene alcohols, rumphellolides C-F (3-6), were isolated from the Formosan gorgonian coral Rumphella antipathies. The structures of the above new natural products were established on the basis of extensive spectral data analysis. Rumphellolides A (1), D (4), E (5), and F (6) showed weak antibacterial activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthozoa / chemistry*
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Escherichia coli / drug effects
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Freeze Drying
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Molecular Conformation
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Pseudomonas aeruginosa / drug effects
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Sesquiterpenes / chemistry*
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology*
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Spectrometry, Mass, Electrospray Ionization
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Staphylococcus aureus / drug effects
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Vibrio parahaemolyticus / drug effects
Substances
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Anti-Bacterial Agents
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Sesquiterpenes