Dillapiol and Apiol as specific inhibitors of the biosynthesis of aflatoxin G1 in Aspergillus parasiticus

Mehdi Razzaghi-Abyaneh; Tomoya Yoshinari; Masoomeh Shams-Ghahfarokhi; Mohammad-Bagher Rezaee; Hiromichi Nagasawa; Shohei Sakuda

doi:10.1271/bbb.70264

Dillapiol and Apiol as specific inhibitors of the biosynthesis of aflatoxin G1 in Aspergillus parasiticus

Biosci Biotechnol Biochem. 2007 Sep;71(9):2329-32. doi: 10.1271/bbb.70264. Epub 2007 Sep 7.

Authors

Mehdi Razzaghi-Abyaneh¹, Tomoya Yoshinari, Masoomeh Shams-Ghahfarokhi, Mohammad-Bagher Rezaee, Hiromichi Nagasawa, Shohei Sakuda

Affiliation

¹ Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.

PMID: 17827697
DOI: 10.1271/bbb.70264

Abstract

Dillapiol was isolated from the essential oil of dill as a specific inhibitor of aflatoxin G1 production. It inhibited aflatoxin G1 production by Aspergillus parasiticus with an IC50 value of 0.15 microM without inhibiting aflatoxin B1 production or fungal growth. Apiol and myristicin, congeners of dillapiol, showed similar activity with IC50 values of 0.24 and 3.5 microM, respectively.

MeSH terms

Aflatoxins / biosynthesis*
Aflatoxins / chemistry*
Allyl Compounds
Aspergillus / chemistry*
Dioxoles / chemistry*
Molecular Structure

Substances

Aflatoxins
Allyl Compounds
Dioxoles
aflatoxin G1
5-allyl 6,7-dimethoxy 1,3-benzodioxole
apiole