(1R,2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production

Bioorg Med Chem Lett. 2007 Nov 1;17(21):5983-8. doi: 10.1016/j.bmcl.2007.07.075. Epub 2007 Aug 21.

Abstract

Synthesis, pharmacology, and pharmacokinetic profiles of (1R, 2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile are reported. This compound demonstrated remarkable potency for stimulating hair growth in a male C3H mouse model as well as reducing sebum production in the male Syrian hamster ear model.

MeSH terms

  • Androgen Antagonists / pharmacology*
  • Animals
  • Cricetinae
  • Hair / growth & development*
  • Hydrocarbons, Fluorinated / pharmacokinetics
  • Hydrocarbons, Fluorinated / pharmacology*
  • Male
  • Mesocricetus
  • Mice
  • Models, Molecular
  • Nitriles / pharmacokinetics
  • Nitriles / pharmacology*
  • Sebum*

Substances

  • (1R,2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile
  • Androgen Antagonists
  • Hydrocarbons, Fluorinated
  • Nitriles