A 67-year-old woman referred to our clinic complaining of decrease in vision and metamorphopsia for 1 month after initiating latanoprost therapy. Fundus examination and optical coherence tomography (OCT) revealed serous detachment in the macula. The macular thickness measured by OCT was 532 microm. Latanoprost was discontinued. At follow-up, a progressive decrease in macular thickness and increase in visual acuity was observed. Four months later, serous detachment was completely resolved, and macular thickness measured by OCT was 186 mum. Latanoprost may lead a serous retinal detachment in the posterior pole. Clinicians should keep in mind that decreased visual acuity in patients using latanoprost might be related with this complication.