In the process of investigating the function of the 18 P450s that make up the CYPome in the soil bacterium Streptomyces coelicolor, we have discovered new and novel biochemical features of some of these monooxygenases. This article which is dedicated to Ron Estabrook summarizes these discoveries with emphasis on their novelty. It is concluded from this work that there are many interesting features of P450 enzymes waiting to be discovered. Since there are more than 6500 P450 gene sequences known today, we can expect that many new biochemical aspects of P450s will be discovered as these individual monooxygenases are investigated.