Synthesis of new enantiomerically enriched beta-Hydroxy-gamma-amino phosphines by selective transformation of naturally occurring amino acids

Chiara Ciardi; Antonio Romerosa; Manuel Serrano-Ruiz; Luca Gonsalvi; Maurizio Peruzzini; Gianna Reginato

doi:10.1021/jo070915x

Synthesis of new enantiomerically enriched beta-Hydroxy-gamma-amino phosphines by selective transformation of naturally occurring amino acids

J Org Chem. 2007 Sep 28;72(20):7787-9. doi: 10.1021/jo070915x. Epub 2007 Sep 5.

Authors

Chiara Ciardi¹, Antonio Romerosa, Manuel Serrano-Ruiz, Luca Gonsalvi, Maurizio Peruzzini, Gianna Reginato

Affiliation

¹ Area de Química InorgAnica, Facultad de Ciencias Experimentales, Universidad de Almería, 04071 Almería, Spain.

PMID: 17784771
DOI: 10.1021/jo070915x

Abstract

Ring opening of amino epoxides derived from naturally occurring amino acids with lithium diphenylphosphido borane is reported as an efficient approach to a new family of enantiomerically enriched multifunctional phosphines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amines / chemistry*
Amino Acids / chemistry*
Epoxy Compounds / chemistry
Phosphines / chemical synthesis*
Stereoisomerism

Substances

Amines
Amino Acids
Epoxy Compounds
Phosphines