Determination of [201Tl]Tl(III) in [201Tl]TlCl solutions using HPLC

M Akhlaghi; M Kamalidehghan; A R Jalilian; N Shadanpoor

doi:10.1016/j.apradiso.2007.07.023

Determination of [201Tl]Tl(III) in [201Tl]TlCl solutions using HPLC

Appl Radiat Isot. 2008 Apr;66(4):479-81. doi: 10.1016/j.apradiso.2007.07.023. Epub 2007 Aug 6.

Authors

M Akhlaghi¹, M Kamalidehghan, A R Jalilian, N Shadanpoor

Affiliation

¹ Nuclear Medicine Group, Agriculture, Medicine and Industrial Research School, Nuclear Science & Technology Research Institute, Moazzen Blvd., Rajaeeshahr, PO Box 31485-498, Karaj, Iran. makhlaghi@nrcam.org

PMID: 17768056
DOI: 10.1016/j.apradiso.2007.07.023

Abstract

A high-performance liquid chromatography technique has been presented to measure the [(201)Tl]TlCl(3) impurity in [(201)Tl]TlCl radiopharmaceutical for precise determination of radiochemical purity. Diethylene tetraamine pentaacetic acid (DTPA) has been used for complete complexation of [(201)Tl]Tl(III). [(201)Tl]Tl(III)-DTPA was analyzed in the presence of [(201)Tl]Tl(I) using a cation exchange HPLC column.

MeSH terms

Chromatography, High Pressure Liquid / methods*
Pentetic Acid / chemistry
Radiopharmaceuticals / analysis*
Thallium / analysis*
Thallium / chemistry

Substances

Radiopharmaceuticals
thallium chloride
Pentetic Acid
Thallium