Two cases of cicatricial pemphigoid showing atypical immunofluorescent findings

Ann Ophthalmol. 1991 Nov;23(11):434-8.

Abstract

We describe two patients with the clinical symptoms of cicatricial pemphigoid (CP). Biopsy specimens of the conjunctiva were taken. Histologic examination revealed subepidermal bullae and infiltration of inflammatory mononuclear cells. Direct immunofluorescent study showed immunoglobulins bound to the basement membrane zone (BMZ) in these patients. The patients also had intercellular immunoglobulin deposition in the conjunctival epithelium. No circulating anti-BMZ antibodies were detected, but one patient had a circulating antiintercellular antibody. Rare cases of CP with atypical immunofluorescent findings are reported.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antibodies, Antinuclear / analysis
  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / pathology
  • Basement Membrane / immunology
  • Conjunctival Diseases / immunology*
  • Conjunctival Diseases / pathology
  • Female
  • Fluorescent Antibody Technique
  • Humans
  • Immunoglobulins / analysis
  • Pemphigoid, Benign Mucous Membrane / immunology*
  • Pemphigoid, Benign Mucous Membrane / pathology

Substances

  • Antibodies, Antinuclear
  • Immunoglobulins