Abstract
We conducted a retrospective study of 65 patients with chronic hepatitis C, to determine whether the secondary structure of the amino-terminal 120 residues of the hepatitis C virus (HCV) NS3 protein is associated with an increased risk of development of hepatocellular carcinoma (HCC). The cumulative incidence of HCC was highest among patients infected with group B HCV-1b, wherein the risk of HCC significantly increased compared with that among patients infected with group A (hazard ratio, 4.95 [95% CI, 1.43-17.11]) after adjustment for age and histological stage. This HCV-1b grouping may be a useful marker for detecting the risk of development of HCC.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Carcinoma, Hepatocellular / epidemiology
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Carcinoma, Hepatocellular / virology*
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Female
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Hepacivirus / classification*
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Hepacivirus / genetics
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Hepacivirus / pathogenicity
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Hepatitis C, Chronic / complications*
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Hepatitis C, Chronic / epidemiology
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Hepatitis C, Chronic / virology
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Humans
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Incidence
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Liver Neoplasms / epidemiology
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Liver Neoplasms / virology*
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Male
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Middle Aged
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Proportional Hazards Models
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Protein Structure, Secondary
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Risk Factors
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Viral Nonstructural Proteins / chemistry*
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Viral Nonstructural Proteins / genetics
Substances
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NS3 protein, hepatitis C virus
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Viral Nonstructural Proteins