Abstract
Control of eukaryotic gene expression requires interaction between sequence-specific transcription factors and their regulatory elements on the particular promoter. The dynamic alteration of chromatin structure regulates the accessibility of these elements in the genome and therefore contributes to the control of transcriptional activity. Here we discuss chromatin remodelling in the context of osteoblast lineage regulation. This review specifically highlights the role of the protein chromatin-related mesenchymal modulator (CReMM/CHD9), a recently identified chromatin remodeler, in osteogenic cell differentiation.
MeSH terms
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Adenosine Triphosphate / metabolism
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Animals
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Cell Differentiation / genetics
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Cell Differentiation / physiology
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Chromatin Assembly and Disassembly / genetics
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Chromatin Assembly and Disassembly / physiology*
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / physiology
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Humans
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Mesenchymal Stem Cells / cytology
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Mesenchymal Stem Cells / metabolism
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Osteoblasts / cytology
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Osteoblasts / metabolism*
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Osteogenesis / genetics*
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Osteogenesis / physiology*
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Promoter Regions, Genetic
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Receptors, Cytoplasmic and Nuclear / metabolism
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Trans-Activators / genetics
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Trans-Activators / physiology
Substances
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DNA-Binding Proteins
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Receptors, Cytoplasmic and Nuclear
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Trans-Activators
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Adenosine Triphosphate