Abstract
The previously reported negative regulatory activity of HIM-8 on the Sox protein EGL-13 is shared by the HIM-8-related ZIM proteins. Furthermore, mutation of HIM-8 can modulate the effects of substitution mutations in the DNA-binding domains of at least four other transcription factors, suggesting broad regulatory activity by HIM-8.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Amino Acid Substitution
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Animals
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Caenorhabditis elegans Proteins / genetics*
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Caenorhabditis elegans Proteins / physiology
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Cell Cycle Proteins / genetics
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Cell Cycle Proteins / physiology*
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Chromosomal Proteins, Non-Histone / physiology*
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DNA-Binding Proteins / genetics
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Gene Expression Regulation
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Genes, Helminth
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Transcription Factors / physiology*
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Zinc Fingers
Substances
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Caenorhabditis elegans Proteins
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Cell Cycle Proteins
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Chromosomal Proteins, Non-Histone
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DNA-Binding Proteins
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HIM-8 protein, C elegans
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Transcription Factors
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Zim-1 protein, C elegans
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Zim-2 protein, C elegans
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Zim-3 protein, C elegans