Abstract
Structure-based design of libraries of multi-component reaction products yields novel potent anti-tuberculosis compounds. Synthesis and preliminary biological results are presented.
MeSH terms
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Animals
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Antitubercular Agents / chemical synthesis*
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Antitubercular Agents / chemistry
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Antitubercular Agents / pharmacology*
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Chlorocebus aethiops
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Gene Library
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Humans
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In Vitro Techniques
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Isoniazid / pharmacology
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Macrophages / drug effects
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / genetics*
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Proteome
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Vero Cells
Substances
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Antitubercular Agents
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Proteome
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Isoniazid