In vivo proton magnetic resonance spectroscopy assessment for muscle metabolism in neuromuscular diseases

J Pediatr. 2007 Sep;151(3):319-21. doi: 10.1016/j.jpeds.2007.05.026.

Abstract

Muscle metabolites were obtained by in vivo proton magnetic resonance spectroscopy of 3 patients with Duchenne muscular dystrophy (DMD), 6 patients with spinal muscular atrophy (SMA), and 10 normal volunteers. Patients with DMD and SMA had lower trimethyl amide (TMA)/water and TMA/total creatine (tCr) ratios but normal tCr/water ratios.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / metabolism
  • Adolescent
  • Child
  • Child, Preschool
  • Creatine / metabolism
  • Female
  • Humans
  • Magnetic Resonance Spectroscopy
  • Male
  • Methylamines / metabolism
  • Muscle, Skeletal / metabolism*
  • Muscular Atrophy, Spinal / metabolism*
  • Muscular Dystrophy, Duchenne / metabolism*

Substances

  • Methylamines
  • trimethylamine
  • Creatine