Mild cognitive impairment and dementia

Annu Rev Clin Psychol. 2006:2:379-88. doi: 10.1146/annurev.clinpsy.1.102803.144039.

Abstract

Mild cognitive impairment (MCI) is a clinical syndrome thought to represent the transition between normal function and dementia. This review describes data that support the existence of such a transitional phase, outlines the heterogeneity of MCI and how that has influenced the evolving concept of MCI, and discusses the impact of heterogeneity on recent MCI clinical trials.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / diagnosis
  • Alzheimer Disease / psychology
  • Cholinesterase Inhibitors / therapeutic use
  • Clinical Trials as Topic / statistics & numerical data
  • Cognition Disorders / diagnosis*
  • Cognition Disorders / drug therapy
  • Cognition Disorders / psychology
  • Dementia / diagnosis*
  • Dementia / psychology
  • Donepezil
  • Humans
  • Indans / therapeutic use
  • Models, Psychological
  • Neuropsychological Tests / statistics & numerical data
  • Piperidines / therapeutic use
  • Syndrome
  • Terminology as Topic
  • Treatment Outcome

Substances

  • Cholinesterase Inhibitors
  • Indans
  • Piperidines
  • Donepezil