Benchtop phase-contrast X-ray imaging

Appl Radiat Isot. 2007 Dec;65(12):1337-44. doi: 10.1016/j.apradiso.2007.07.009. Epub 2007 Jul 22.

Abstract

Clinical radiography has traditionally been based on contrast obtained from absorption when X-rays pass through the body. The contrast obtained from traditional radiography can be rather poor, particularly when it comes to soft tissue. A wide range of media of interest in materials science, biology and medicine exhibit very weak absorption contrast, but they nevertheless produce significant phase shifts with X-rays. The use of phase information for imaging purposes is therefore an attractive prospect. Some of the X-ray phase-contrast imaging methods require highly monochromatic plane wave radiation and sophisticated X-ray optics. However, the propagation-based phase-contrast imaging method adapted in this paper is a relatively simple method to implement, essentially requiring only a microfocal X-ray tube and electronic detection. In this paper, we present imaging results obtained from two different benchtop X-ray sources employing the free space propagation method. X-ray phase-contrast imaging provides higher contrast in many samples, including biological tissues that have negligible absorption contrast.

MeSH terms

  • Animals
  • Humans
  • Interferometry
  • Phantoms, Imaging
  • Radiobiology
  • Radiography / methods*
  • Synchrotrons
  • Wasps / anatomy & histology
  • X-Rays