Abstract
Glioma is a highly invasive, rapidly spreading form of brain cancer that is resistant to surgical and medical treatment. The recent progresses made in intracellular and ion channels of glioma cells provide a potential new approach for biochemical therapy of brain tumor. In this paper, we reviewed clinical data on chemotherapy by temozolomide and results from new studies on voltage-gated potassium channels, large-conductance Ca(2+)-activated K(+) channels, volume-activated chloride channels, glioma-specific chloride channel and their modulators. These new findings may represent future directions for brain tumor studies and treatment.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antineoplastic Agents, Alkylating / therapeutic use
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Brain Neoplasms / drug therapy*
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Brain Neoplasms / metabolism
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Brain Neoplasms / pathology
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Dacarbazine / analogs & derivatives*
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Dacarbazine / chemistry
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Dacarbazine / therapeutic use
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Glioma / drug therapy*
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Glioma / metabolism
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Glioma / pathology
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Humans
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Indoles / chemistry
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Indoles / therapeutic use
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Models, Biological
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Molecular Structure
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Potassium Channel Blockers / therapeutic use
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Potassium Channels, Calcium-Activated / antagonists & inhibitors
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Potassium Channels, Calcium-Activated / metabolism
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Temozolomide
Substances
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Antineoplastic Agents, Alkylating
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Indoles
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Potassium Channel Blockers
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Potassium Channels, Calcium-Activated
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paxilline
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Dacarbazine
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Temozolomide