Recovery from cisplatin-induced ototoxicity: a case report and review

Int J Pediatr Otorhinolaryngol. 2007 Oct;71(10):1631-8. doi: 10.1016/j.ijporl.2007.06.021. Epub 2007 Aug 15.

Abstract

We present a pediatric case report of cisplatin-induced ototoxicity with subsequent recovery. The patient experienced tinnitus and fluctuating mild high-frequency sensorineural hearing loss (SNHL) with a concomitant decrease in distortion product otoacoustic emissions (DPOAE). There was recovery of hearing loss and return of DPOAE at 1 year after completion of cisplatin therapy. Reports of recovery from cisplatin-induced ototoxicity in humans are limited in the literature, especially in the pediatric population. A review of cisplatin ototoxicity and mechanisms of recovery are discussed, with an emphasis on the particular chemotherapy regimen and dosing schedule in this case, given at 4-11 week intervals.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acoustic Stimulation
  • Adolescent
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use
  • Bone Neoplasms / drug therapy*
  • Cisplatin / adverse effects*
  • Cisplatin / therapeutic use
  • Cochlea / drug effects
  • Cochlea / physiopathology
  • Hearing Loss, Sensorineural / chemically induced*
  • Hearing Loss, Sensorineural / diagnosis
  • Hearing Loss, Sensorineural / physiopathology
  • Humans
  • Humerus / pathology*
  • Male
  • Osteosarcoma / drug therapy*
  • Recovery of Function*
  • Severity of Illness Index
  • Tinnitus / chemically induced
  • Tinnitus / diagnosis
  • Tinnitus / physiopathology

Substances

  • Antineoplastic Agents
  • Cisplatin