Abstract
Reaction of [RuCl(3)(dppb)H(2)O] (dppb=1,4 bis(diphenylphospine)butane) with 2-benzoylpyridine thiosemicarbazone (H2Bz4DH) and its N(4)-methyl (H2Bz4M) and N(4)-phehyl (H2Bz4Ph) derivatives gave [RuCl(dppb)(H2Bz4DH)]Cl (1), [RuCl(dppb)(H2Bz4M)]Cl (2) and [RuCl(dppb)(H2Bz4Ph)]Cl (3). The cytotoxic activity of the studied compounds was tested against the MCF-7, TK-10 and UACC-62 human tumor cell lines. The precursor [RuCl(3)(dppb)H(2)O] exhibits cytocidal activity against the tree cell lines. H2BzDH, H2Bz4M, and [RuCl(dppb)(H2Bz4M)]Cl (2) show a selective cytocidal effect against the UACC-62 cell line which makes them the most promising compounds.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / pharmacology
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Benzyl Compounds / chemistry
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Benzyl Compounds / pharmacology*
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Cell Death / drug effects
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Colchicine / pharmacology
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Drug Screening Assays, Antitumor
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Electrochemistry
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Etoposide / pharmacology
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Humans
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Magnetic Resonance Spectroscopy
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Pyridines / chemistry
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Pyridines / pharmacology*
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Ruthenium / chemistry
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Ruthenium / pharmacology*
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Spectrophotometry, Infrared
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Thiosemicarbazones / chemistry
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Thiosemicarbazones / pharmacology*
Substances
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Antineoplastic Agents
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Benzyl Compounds
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Pyridines
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Thiosemicarbazones
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Etoposide
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Ruthenium
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2-benzylpyridine
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Colchicine