Polymorphism of the vWA locus located in the center of the three vWA STRs in the Japanese population

Hirofumi Tsutsumi; Toshinobu Komuro; Rei Mukoyama; Hiroaki Nogami

doi:10.1016/j.legalmed.2007.05.008

Polymorphism of the vWA locus located in the center of the three vWA STRs in the Japanese population

Leg Med (Tokyo). 2008 Jan;10(1):31-4. doi: 10.1016/j.legalmed.2007.05.008. Epub 2007 Aug 14.

Authors

Hirofumi Tsutsumi¹, Toshinobu Komuro, Rei Mukoyama, Hiroaki Nogami

Affiliation

¹ Department of Legal Medicine, Nihon University School of Dentistry, Tokyo 101-8310, Japan.

PMID: 17698394
DOI: 10.1016/j.legalmed.2007.05.008

Abstract

The structural polymorphism of the vWA locus (vWA-T) located between the two polymorphic vWA loci (vWA-K and -P) was analyzed in 100 Japanese individuals using DNA samples isolated from dental pulp. The polymorphism of this locus was based on the difference in the number of tcta repeat. New interallele 11.1 was found in two samples. All together 9 alleles and 19 genotypes were observed. In addition, one mutant allele contained tcga in the common tcta repeat structure. The value of PD was calculated to be 0.900. Inheritance of the polymorphism was confirmed in a family including 23 individuals and 6 matings.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Asian People / genetics*
Electrophoresis, Polyacrylamide Gel
Gene Frequency
Genetics, Population*
Genotype
Humans
Japan
Polymerase Chain Reaction
Polymorphism, Genetic*
Tandem Repeat Sequences*
von Willebrand Factor / genetics*

Substances

von Willebrand Factor