Abstract
The quinolone analog SQ-4004 has been identified as a potentially excellent anti-ischemic agent, which exhibited highly potent efficacy in reducing infarct volume size in vivo rat MCAO model (32.1% at 0.01mg/kg) and potent cardioprotective effect at myocardial infarction in vivo model (26.6% at 0.01mg/kg) while it exhibited highly reduced anti-bacterial activity. The mechanistic study revealed that the anti-ischemic activity might exert via an anti-apoptotic pathway, which implies its therapeutic uses against the ischemic cell injuries including ischemic stroke and ischemic heart disease.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Brain Ischemia / drug therapy
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Brain Ischemia / pathology*
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Cell Line, Tumor
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Cell Survival / drug effects
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Disease Models, Animal
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Humans
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Models, Biological
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Molecular Structure
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Myocardial Infarction / drug therapy
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Myocardial Infarction / pathology
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Quinolines / chemical synthesis
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Quinolines / chemistry*
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Quinolines / pharmacology*
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Quinolines / therapeutic use
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Rats
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Quinolines
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quinoline