Synthesis of functionalised nucleosides for incorporation into nucleic acid-based serine protease mimics

Mieke A Catry; Annemieke Madder

doi:10.3390/12010114

Synthesis of functionalised nucleosides for incorporation into nucleic acid-based serine protease mimics

Molecules. 2007 Jan 31;12(1):114-29. doi: 10.3390/12010114.

Authors

Mieke A Catry¹, Annemieke Madder

Affiliation

¹ Ghent University, Department of Organic Chemistry, Laboratory for Organic and Biomimetic Chemistry, Krijgslaan 281 (S4), Gent, Belgium.

Abstract

The synthesis of nucleosides modified with an extra imidazole, carboxyl and hydroxyl group is described. These nucleosides can be incorporated into an oligonucleotide duplex, thus generating a novel type of serine protease mimic.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Catalytic Domain
Chymotrypsin / chemistry
Chymotrypsin / metabolism
Hydrolysis
Imidazoles / chemistry
Magnetic Resonance Spectroscopy
Models, Biological
Molecular Mimicry
Molecular Structure
Nucleosides / chemical synthesis
Nucleosides / chemistry*
Oligonucleotides / chemistry*
Peptides / chemistry
Peptides / metabolism
Protein Structure, Tertiary
Serine Endopeptidases / chemistry*
Serine Endopeptidases / metabolism

Substances

Imidazoles
Nucleosides
Oligonucleotides
Peptides
imidazole
Serine Endopeptidases
Chymotrypsin
alpha-chymotrypsin