Translational research in medication development for nicotine dependence

Nat Rev Drug Discov. 2007 Sep;6(9):746-62. doi: 10.1038/nrd2361.

Abstract

A major obstacle to the development of medications for nicotine dependence is the lack of animal and human laboratory models with sufficient predictive clinical validity to support the translation of knowledge from laboratory studies to clinical research. This Review describes the animal and human laboratory paradigms commonly used to investigate the pathophysiology of nicotine dependence, and proposes how their predictive validity might be determined and improved, thereby enhancing the development of new medications.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Disease Models, Animal*
  • Drug Design*
  • Humans
  • Models, Neurological*
  • Tobacco Use Disorder / drug therapy*
  • Tobacco Use Disorder / etiology
  • Tobacco Use Disorder / psychology