A 68-year-old woman underwent right colectomy for cancer of the ascending colon, followed by a local recurrence 26 months after surgery. She presented with fever and right lower abdominal pain, and was admitted to the hospital for locally recurrent colorectal cancer and tumor rupture. The patient was treated with a modified (reduced-dose) FOLFOX 4 regimen (mFOLFOX 4). In the four course of this regimen, the serum level of CEA decreased from 268 to 2.3 ng/mL. Even after 8 course, the serum CEA level remained within the normal range (4.7 ng/mL). Our case suggests that the mFOLFOX 4 regimen is effective for advanced or recurrent colorectal cancer with less toxicities including neuropathy,thus enabling patients to undergo long-term therapy.