Abstract
The enantioselective total synthesis of (-)-anisomycin, a potent antibiotic agent, has been achieved. The key steps are a Pd(0)-catalyzed stereoselective intramolecular oxazine formation from d-tyrosine and pyrrolidine formation by catalytic hydrogenation of the oxazine.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anisomycin / chemical synthesis*
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Anisomycin / chemistry
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Catalysis
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Molecular Structure
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Oxazines / chemical synthesis*
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Oxazines / chemistry
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Palladium / chemistry*
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Pyrrolidines / chemistry
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Tyrosine / chemistry
Substances
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Anti-Bacterial Agents
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Oxazines
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Pyrrolidines
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Tyrosine
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Palladium
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Anisomycin