Consultation-liaison (C-L) psychiatry has an important role in the identification and management of psychological problems in patients with medical disorders in general hospitals. The diagnostic tools C-L psychiatrists are usually provided with may reveal to be limited because of particular psychosomatic syndromes and subthreshold psychopathology that are undetected by psychiatric diagnostic criteria. The Diagnostic Criteria for Psychosomatic Research (DCPR) were developed with the aim of providing clinicians with operational criteria for psychosomatic syndromes to overcome the limitations shown by the most often diagnosed disorders in medical settings as adjustment, somatoform, mood, and anxiety disorders. In a group of 66 consecutive C-L psychiatry inpatients, a consistent prevalence of 71% DCPR syndromes was found, particularly secondary functional somatic symptoms, persistent somatization, health anxiety, and demoralization. Their overlap rates with DSM-IV diagnoses showed that the DCPR syndromes were able to identify psychological dimensions (as somatic symptom clustering, anxiety triggered by the current health status, and a feeling state of hopelessness) that do not meet or are not detected by DSM-IV. Furthermore, the DCPR syndromes identified patients with clinically significant functional impairment. These results replicate previous findings in C-L psychiatry using the DCPR categories and pave the way for further research to clarify their mediating role in the course and the outcome variance of medical and psychological problems of hospital inpatients referred for psychiatric consultation.