Abstract
A series of cinnamyl compounds related to 2'-hydroxycinnamaldehyde were synthesized and their antitumor effects against human cancer cells evaluated. Hydroxylamine derivative 6 inhibited the growth of human cancer cells and human colon tumor xenograft in nude mice. Its antitumor effects belong to the induction of apoptosis and arresting cell cycle at G(2)/M phase, which is confirmed by detection of apoptosis markers and cell cycle analysis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Apoptosis / drug effects
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Caspase 3 / biosynthesis
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Cell Cycle / drug effects
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Cell Division / drug effects
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Cell Line, Tumor
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Cinnamates / chemical synthesis*
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Cinnamates / pharmacology*
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Cinnamomum / chemistry
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Dose-Response Relationship, Drug
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / pharmacology
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G2 Phase / drug effects
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Humans
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Mice
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Mice, Nude
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Neoplasm Transplantation
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Poly(ADP-ribose) Polymerase Inhibitors
Substances
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Antineoplastic Agents
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Cinnamates
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Enzyme Inhibitors
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Poly(ADP-ribose) Polymerase Inhibitors
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Caspase 3