Abstract
Using our high-throughput hepatitis C replicon assay to screen a library of over 8,000 novel diversity-oriented synthesis (DOS) compounds, we identified several novel compounds that regulate hepatitis C virus (HCV) replication, including two libraries of epoxides that inhibit HCV replication (best 50% effective concentration, < 0.5 microM). We then synthesized an analog of these compounds with optimized activity.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology*
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Computer Simulation
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Cytopathogenic Effect, Viral / drug effects
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Drug Design
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Drug Evaluation, Preclinical
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Epoxy Compounds / chemical synthesis*
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Epoxy Compounds / pharmacology*
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Hepacivirus / drug effects*
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Maleimides / pharmacology
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Replicon / drug effects
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Reproducibility of Results
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Structure-Activity Relationship
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Virus Replication / drug effects*
Substances
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Antiviral Agents
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Epoxy Compounds
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Maleimides
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maleimide