Heavy isotopes to avert ageing?

Trends Biotechnol. 2007 Sep;25(9):371-5. doi: 10.1016/j.tibtech.2007.07.007. Epub 2007 Aug 2.

Abstract

Oxidative modifications of cellular components by free radicals are thought to be the cause of ageing and age-associated diseases. Extensive prior research has aimed to lessen such damage by counteracting the free-radical oxidizers with antioxidants, but there have been no attempts to protect the oxidizer-targeted biomolecules by making them more stable against oxidation. A recent paper describes an original and promising method based on the use of non-radioactive heavy isotopes, which might enable living cells to resist the free-radical oxidation and consequently allow us to live a healthier, longer life.

MeSH terms

  • Aging / metabolism*
  • Amino Acids, Essential / chemistry*
  • Carbon Isotopes / metabolism*
  • Humans
  • Kinetics
  • Nutritional Physiological Phenomena
  • Oxidative Stress*
  • Reactive Oxygen Species / chemistry

Substances

  • Amino Acids, Essential
  • Carbon Isotopes
  • Reactive Oxygen Species