Abstract
Apoptosis was long considered the major mechanism of programmed cell death. However, results obtained during the last years have proved that chemotherapeuticals as well as a number of other factors may induce modes of cell death different from apoptosis. The identified mechanisms include mitotic catastrophe, autophagy, necrosis and, in the context of cancer therapy, senescence. The purpose of the following review is a general description of these processes.
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology
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Apoptosis / drug effects
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Apoptosis / physiology*
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Autophagy / drug effects
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Autophagy / physiology*
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Caspases / metabolism
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Cell Death / drug effects
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Cell Death / physiology*
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Cell Membrane Permeability / drug effects
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Cell Survival / physiology
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Cellular Senescence / physiology
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Humans
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Mice
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Mitochondria / metabolism
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Mitosis / drug effects
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Mitosis / physiology
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Models, Biological*
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Necrosis / metabolism*
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Neoplasms / drug therapy
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Neoplasms / pathology
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Spindle Apparatus / drug effects
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Spindle Apparatus / metabolism
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Telomerase / metabolism
Substances
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Antineoplastic Agents
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Telomerase
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Caspases