Anticancer effects of a Chinese herbal medicine, juzen-taiho-to, in combination with or without 5-fluorouracil derivative on DNA-synthesizing enzymes in 1,2-dimethylhydrazine induced colonic cancer in rats

Am J Chin Med. 1991;19(3-4):233-41. doi: 10.1142/S0192415X91000314.

Abstract

Juzen-taiho-to (JTT; [Shi-quan-da-bu-tang], a Japanese modified Chinese herbal prescription) in combination with an anticancer drug UFT (5-fluorouracil derivative) prevented the body weight loss and the induction of the colonic cancer in rats treated with a chemical carcinogen 1,2-dimethylhydrazine (DMH), and suppressed markedly the activity of thymidylate synthetase (TS) involved in the de novo pathway of pyrimidine synthesis in colonic cancer induced by DMH.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / drug therapy*
  • Adenocarcinoma / enzymology
  • Adenocarcinoma / pathology
  • Animals
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / pharmacology
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Colonic Neoplasms / drug therapy*
  • Colonic Neoplasms / enzymology
  • Colonic Neoplasms / pathology
  • Drug Evaluation, Preclinical
  • Drugs, Chinese Herbal / administration & dosage*
  • Fluorouracil / administration & dosage*
  • Neoplasm Staging
  • Rats
  • Thymidine Kinase / drug effects
  • Thymidylate Synthase / drug effects*
  • Weight Loss / drug effects

Substances

  • Drugs, Chinese Herbal
  • juzentaihoto
  • Thymidylate Synthase
  • Thymidine Kinase
  • Fluorouracil