A high-sodium diet in streptozotocin-induced diabetic rats impairs endothelium-derived hyperpolarizing factor-mediated vasodilation

Yasutoshi Hirabara; Mina Araki; Mio Fukuda; Shiori Katafuchi; Kenji Honda; Ryo Saito; Yukio Takano

doi:10.1254/jphs.sc0070091

A high-sodium diet in streptozotocin-induced diabetic rats impairs endothelium-derived hyperpolarizing factor-mediated vasodilation

J Pharmacol Sci. 2007 Aug;104(4):402-5. doi: 10.1254/jphs.sc0070091. Epub 2007 Aug 4.

Authors

Yasutoshi Hirabara¹, Mina Araki, Mio Fukuda, Shiori Katafuchi, Kenji Honda, Ryo Saito, Yukio Takano

Affiliation

¹ Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.

PMID: 17675792
DOI: 10.1254/jphs.sc0070091

Abstract

We examined endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation of mesenteric arteries in high-sodium loaded streptozotocin (STZ)-induced diabetic rats. The study shows that acetylcholine (ACh)-induced, EDHF-mediated relaxation is relatively maintained in STZ-induced diabetic rats, but after a high-sodium diet was given, the function was significantly impaired in STZ-induced diabetic rats.

MeSH terms

Acetylcholine
Animals
Biological Factors / metabolism*
Blood Pressure / drug effects
Diabetes Mellitus, Experimental / physiopathology*
Heart Rate / drug effects
Male
Mesenteric Arteries / physiopathology
Phenylephrine
Rats
Rats, Wistar
Sodium, Dietary / administration & dosage
Sodium, Dietary / adverse effects*
Streptozocin
Vasodilation / drug effects*

Substances

Biological Factors
Sodium, Dietary
endothelium-dependent hyperpolarization factor
Phenylephrine
Streptozocin
Acetylcholine