Recent research projects have shown a good suitability of the ozonation process to transform trace concentrations of most pharmaceuticals in wastewater treatment plant (WWTP) effluents. The concentrations of carbamazepine and 17 alpha-ethinylestradiol, for instance, were reduced below their detection limits by use of ozone dosages resulting in a specific ozone consumption of 0.5 mg O3/mg DOC0. At the same time a good disinfection performance was achieved. The given hygienic requirements of the EU bathing water directive (e.g. 2,000 N/100 mL faecal coliforms) are fulfilled without the formation of bromate (<10 microg/L). As technical control parameter of the ozonation process usually the residual ozone in the liquid phase or in the off-gas are used. However, at very low specific ozone consumptions, ozone reacts instantaneously with dissolved compounds and cannot be detected. Hence, alternative parameters should be used for effective operation control. The present paper evaluates the relation between UVA decrease and the removal of different compounds (endocrine disrupting compounds, pharmaceuticals, iodinated X-ray contrast media), microbial parameters and bromate formation. The results can be used as a guideline for the control of the oxidation performance at large scale ozonation units.