Abstract
The human enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) forms heteropolymers with the rodent enzyme in man-rodent somatic cell hybrids. A gene specifying GAPDH is syntenic with the genes specifying the glycolytic enzymes triosephosphate isomerase (TPI) and lactate dehydrogenase B (LDH-B). The synteny of GAPDH, TPI, and LDH-B is the first evidence for the syntenic association of human genes that specify enzymes of the Embden-Meyerhof glycolytic pathway.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Chromosome Mapping
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Chromosomes, Human, 6-12 and X*
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Genes*
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Genetic Linkage*
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Glyceraldehyde-3-Phosphate Dehydrogenases / biosynthesis*
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Humans
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Hybrid Cells / enzymology*
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L-Lactate Dehydrogenase / biosynthesis
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NAD / metabolism
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Protein Conformation
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Rodentia
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Triose-Phosphate Isomerase / biosynthesis
Substances
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NAD
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L-Lactate Dehydrogenase
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Glyceraldehyde-3-Phosphate Dehydrogenases
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Triose-Phosphate Isomerase