Biologically active indole alkaloids from Kopsia arborea

Kuan-Hon Lim; Osamu Hiraku; Kanki Komiyama; Takashi Koyano; Masahiko Hayashi; Toh-Seok Kam

doi:10.1021/np0702234

Biologically active indole alkaloids from Kopsia arborea

J Nat Prod. 2007 Aug;70(8):1302-7. doi: 10.1021/np0702234. Epub 2007 Aug 1.

Authors

Kuan-Hon Lim¹, Osamu Hiraku, Kanki Komiyama, Takashi Koyano, Masahiko Hayashi, Toh-Seok Kam

Affiliation

¹ Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.

PMID: 17665953
DOI: 10.1021/np0702234

Abstract

Nine new indole alkaloids, rhazinoline (1), 19(S)-methoxytubotaiwine (2), 19(R)-methoxytubotaiwine (3), kopsamidine A (4), kopsamidine B (5), kopsinidine A (6), kopsinidine B (7), paucidactine C (8), and pericine N-oxide (9), in addition to several recently reported novel indoles and 34 other known ones, were obtained from the stem-bark extract of the Malayan Kopsia arborea. The structures were determined using NMR and MS analysis. Valparicine (12) showed pronounced cytotoxic effects against KB and Jurkat cells (IC(50) 13.0 and 0.91 microM, respectively).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology*
Apocynaceae / chemistry*
Drug Screening Assays, Antitumor
Humans
Indole Alkaloids / chemistry
Indole Alkaloids / isolation & purification*
Indole Alkaloids / pharmacology*
Jurkat Cells
KB Cells
Malaysia
Nuclear Magnetic Resonance, Biomolecular
Plant Bark / chemistry
Plant Stems / chemistry
Plants, Medicinal / chemistry*

Substances

Antineoplastic Agents, Phytogenic
Indole Alkaloids
valparicine