Metal-mediated peptide assembly: use of metal coordination to change the oligomerization state of an alpha-helical coiled-coil

Mikhail V Tsurkan; Michael Y Ogawa

doi:10.1021/ic700958h

Metal-mediated peptide assembly: use of metal coordination to change the oligomerization state of an alpha-helical coiled-coil

Inorg Chem. 2007 Aug 20;46(17):6849-51. doi: 10.1021/ic700958h. Epub 2007 Jul 28.

Authors

Mikhail V Tsurkan¹, Michael Y Ogawa

Affiliation

¹ Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, OH 43403, USA.

PMID: 17661463
DOI: 10.1021/ic700958h

Abstract

Metal coordination is used to alter the oligomerization state of a designed peptide structure. The 30-residue polypeptide AQ-Pal14Pal21contains two metal-binding 4-pyridylalanine (Pal) residues on its solvent-exposed surface and exists as a very stable two-stranded alpha-helical coiled-coil. Upon the addition of Pt(en)(NO3)2, a significant conformational change to a metal-bridged, four-helix bundle is seen.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Alanine / analogs & derivatives*
Amino Acid Sequence
Molecular Sequence Data
Peptides / chemical synthesis*
Peptides / chemistry*
Platinum / chemistry*
Protein Structure, Secondary
Pyridines / chemistry*

Substances

Peptides
Pyridines
Platinum
pyridine
Alanine