Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage

Breast Cancer Res. 2007;9(4):304. doi: 10.1186/bcr1740.

Abstract

Estrogen-mediated proliferation is fundamental to normal mammary gland development. Recent studies have demonstrated that amphiregulin is a critical paracrine regulator of estrogen action during ductal morphogenesis. These studies implicate a critical role for amphiregulin in mammary stem cell differentiation as well as breast cancer initiation and progression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amphiregulin
  • Breast / growth & development*
  • Breast / pathology
  • Breast Neoplasms / etiology*
  • Breast Neoplasms / pathology
  • EGF Family of Proteins
  • Estrogens / pharmacology*
  • Glycoproteins / metabolism*
  • Humans
  • Intercellular Signaling Peptides and Proteins / metabolism*

Substances

  • AREG protein, human
  • Amphiregulin
  • EGF Family of Proteins
  • Estrogens
  • Glycoproteins
  • Intercellular Signaling Peptides and Proteins