Abstract
A synthesis of (+/-)-3H-epivincamine is reported. Important steps include (1) a Rh(II)-catalyzed intramolecular [3+2]-cycloaddition of an alpha-diazo indolo amide, (2) a reductive ring opening of the cycloadduct, (3) a decarboethoxylation reaction, and (4) a base-induced keto-amide ring contraction.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antihypertensive Agents / chemical synthesis
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Cyclization
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Rhodium / chemistry*
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Vasodilator Agents / chemical synthesis
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Vincamine / chemical synthesis*
Substances
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Antihypertensive Agents
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Vasodilator Agents
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Vincamine
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Rhodium